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A New York Times Bestseller
Finalist for the Royal Society Insight Investment Science Book Prize
Longlisted for the Wellcome Book Prize
A rigorous, skeptical, deeply reported look at the new science behind the mind's surprising ability to heal the body
Have you ever felt a surge of adrenaline after narrowly avoiding an accident? Salivated at the sight (or thought) of a sour lemon? Felt turned on just from hearing your partner's voice? If so, then you've experienced how dramatically the workings of your mind can affect your body.
Yet while we accept that stress or anxiety can damage our health, the idea of "healing thoughts" was long ago hijacked by New Age gurus and spiritual healers. Recently, however, serious scientists from a range of fields have been uncovering evidence that our thoughts, emotions and beliefs can ease pain, heal wounds, fend off infection and heart disease and even slow the progression of AIDS and some cancers.
In Cure, award-winning science writer Jo Marchant travels the world to meet the physicians, patients and researchers on the cutting edge of this new world of medicine. We learn how meditation protects against depression and dementia, how social connections increase life expectancy and how patients who feel cared for recover from surgery faster. We meet Iraq war veterans who are using a virtual arctic world to treat their burns and children whose ADHD is kept under control with half the normal dose of medication. We watch as a transplant patient uses the smell of lavender to calm his hostile immune system and an Olympic runner shaves vital seconds off his time through mind-power alone.
Drawing on the very latest research, Marchant explores the vast potential of the mind's ability to heal, lays out its limitations and explains how we can make use of the findings in our own lives. With clarity and compassion, Cure points the way towards a system of medicine that treats us not simply as bodies but as human beings.
- Sales Rank: #11374 in Books
- Published on: 2017-01-10
- Released on: 2017-01-10
- Original language: English
- Dimensions: 7.98" h x .71" w x 5.17" l, .81 pounds
- Binding: Paperback
- 320 pages
Review
A New York Post Best Book of 2016
A New York Magazine Best Science Book of 2016
A Mindful.org Top 10 Mindful Book of 2016
A Sunday Times Book of the Year
An Economist Book of the Year
A Spirituality & Health Best Mind/Body Book of 2016
“Ms. Marchant writes well, which is never a guarantee in this genre… Second, [she] has chosen very moving characters to show us the importance of the research… and she has an equal flair for finding inspirational figures… the studies are irresistible, and they come in an almost infinite variety.”
—New York Times
“Cure is a cautious, scrupulous investigation of how the brain can help heal our bodies. It is also an important look at the flip side of this coin, which is how brains damaged by stress may make bodies succumb to physical illness or accelerated aging…Cure points a way toward a future in which the two camps [mainstream medicine and alternative therapies] might work together. After all, any medicine that makes a patient better, whether conventional, alternative, or placebo, is simply medicine.”
—Wall Street Journal
“A well-researched page-turner… raises questions about the role of culture, environment and neurochemistry in our responses to treatment—and may very well lead to widespread changes in the ways we practice medicine.”
—Susannah Cahalan, New York Post
“Cure is for anyone interested in a readable overview of recent findings in mind-body phenomena, a reliably enthralling topic… A rewarding read that seeks to separate the wishful and emotion-driven from the scientifically tested.”
—Washington Post
“Research-heavy but never dull, this revelatory work about the mind-body connection explains how the brain can affect physical healing.”
—Entertainment Weekly
“Marchant is a skeptical, evidence-based reporter—one with a background in microbiology, no less—which makes for a fascinating juxtaposition against some of the alternative treatments she discusses.”
—New York Magazine
"A thought-provoking exploration of how the mind can affect the body and can be harnessed to help treat physical illness."
—Economist
“In a wide-ranging and compelling new book, science journalist Jo Marchant explores whether the mind can heal the body… With lively, clear prose, Marchant surveys the evidence for the mind-body connection.”
—Science News
“Fascinating and thought-provoking. Marchant has travelled extensively around Europe and the US, talking to health workers and ordinary folk, to produce this meticulously researched book… Cure is a much-needed counter to a reductionist medical culture that ignores anything that doesn’t show up in a scan… [it] should be compulsory reading for all young doctors.”
—New Scientist
“A revved-up, research-packed explication of the use of mind in medicine, from meditation to guided visualisation. Marchant’s nimble reportage on the work of scientists in novel fields such as psychoneuroimmunology and her discussion of placebos are as fresh as her reminders of how stress and poverty affect wellbeing are timely."
—Nature
“Could my belief that I’m going to feel better in itself heal me? It’s a fascinating question, and one that British author Jo Marchant takes on with aplomb in her new book, Cure.”
—Spirituality & Health
“Writing with simplicity, clarity and style, and covering an enormous range of material, [Marchant] surveys with grace what we think we know, and what we would like to know, about the mysterious and troubling relationship between our minds and our bodies… [She] is level-headed, always with one foot planted in the worlds of science and reason. Though open-minded, she is rigorous, her gently skeptical tone reassures, and she gracefully skewers quackery.”
—The Guardian
“Thought-provoking… This new generation of evidence-based mind-body researchers has produced some remarkable findings, which Marchant analyses with elegance and lucidity."
—Times Literary Supplement
“Jo Marchant makes her case so cogently that it is hard to disagree [with her]… The author has a gift for writing that is both clear and vivid, and communicates complex ideas in a way that is comprehensible and uncondescending… This is surely an area of medicine whose time has come.”
—The Independent
"A diligent and useful work that makes the case for 'holistic' medicine while warning against the snake-oil salesmen who have annexed that word for profit."
—Sunday Times
“This is an important book, and one that will challenge those dismissive of efforts to investigate how our thoughts, emotions and beliefs might directly influence our physical wellbeing… The evolving science explored in Cure is intriguing and trailblazing, and Marchant's account of its pursuit is often gripping… There's a lot to this impressive book, and it has the potential to have the same dramatic impact on our understanding of our self as Norman Doidge's blockbuster, The Brain that Changes Itself.”
—Sydney Morning Herald
"Marchant explores the possibilities of psychology-based approaches to improving physical well-being in this open-minded, evidence-based account… A powerful and critically needed conceptual bridge for those who are frustrated with pseudoscientific explanations of alternative therapies but intrigued by the mind’s potential power to both cause and treat chronic, stress-related conditions."
—Publishers Weekly (starred review)
"A balanced, informative review of a controversial subject."
—Kirkus Reviews
"Cure represents a journey in the best sense of the word: a vivid, compassionate, generous exploration of the role of the human mind in both health and illness. Drawing on her training as a scientist and a science writer, Marchant meticulously investigates both promising and improbable theories of the mind’s ability to heal the body. The result is to illuminate a fascinating approach to medicine, full of human detail, integrity, and ultimately, hope.”
—Deborah Blum, author of The Poisoner’s Handbook and Love at Goon Park
“This is popular science writing at its very best. Cure beautifully describes the cutting-edge research going on in the fascinating—and until now, often unexplored—area of mind-body medicine. I would recommend this book to anybody who has a mind and a body.”
—Henry Marsh, author of Do No Harm: Stories of Life, Death, and Brain Surgery
About the Author
Jo Marchant is the author of Decoding the Heavens, shortlisted for the Royal Society Prize. She has a PhD in genetics and medical microbiology and has written on everything from the future of genetic engineering to underwater archaeology for New Scientist, Nature, The Guardian, and Smithsonian. She has appeared on BBC Radio, CNN, and National Geographic. She lives in London.
Excerpt. © Reprinted by permission. All rights reserved.
Chapter 2
Linda Buonanno hugs me as soon as we meet, and shows me upstairs to her small, first-floor apartment in a housing block just off the freeway in Methuen, Massachusetts. Her living space is tidy but densely packed with framed photos, scented candles and an overwhelming preference for the color green. She sits me at the table, in front of a perfectly laid out tea set and a plate of ten macaroons. The 67-year-old is plump with short, auburn hair and a girlish giggle. “Everyone thinks it’s dyed, but it isn’t,” she tells me. She hovers until I try a macaroon, then sits down opposite and tells me about her struggles with irritable bowel syndrome (IBS).
She talks fast. Her symptoms first struck two decades ago, when her marriage of 23 years broke down. Although she dreamed of being a hair- dresser, she was working shifts in a factory, running machinery that made surgical blades, juggling the 60-hour week with a court battle and caring for the two youngest of her four children. “I went through hell,” she says. Within a year of the split, she started suffering from intestinal pains, cramps, diarrhea and bloating.
The condition has affected her ever since, especially at stressful times such as when she was laid off from the factory. Their jobs outsourced to Mexico, the group of women with whom she had worked and bonded was scattered. She retrained as a medical assistant, hoping to find work in a
chiropractor’s office, but once she qualified she found that no one was hiring. When she did finally find a part-time job, she had to give it up because of the pain from her IBS.
The condition has destroyed her social life too. When the symptoms are bad, “I can’t even leave the house,” she says. “I’d be keeling over in pain, running to the bathroom all the time.” Even buying groceries re- quires staying within reach of a bathroom, and she lists the local facilities: one in the Market Basket, one in the post office down the street. “This is 20 years I’ve been doing this,” she says. “It’s a horrible way to live.” Now she has to juggle the condition with looking after her elderly parents— her mother lives alone, while her father, who suffers from dementia, is in a nursing home. Linda’s brother was killed in Vietnam, and her twin sister died of cancer 18 years ago, so she is the only one left to help them.
She brightens. “But I travel,” she says. “I go to England, I do every- thing. I love it.” I’m thrown by this statement until I realize that she’s talking about Google maps. I ask her to show me, and we move over to her computer, which sits on a desk squeezed between the sofa and the micro- wave. She fires up the maps program and lands us on top of Buckingham Palace in London.
Suddenly I get a sense of how much time Linda has spent in this flat. She knows the layout of the palace intimately, zooming in to try to peek through the windows, then flying around the back to check out the private gardens. Other favorite destinations include the Caribbean island of Aruba, and the celebrity mansions of Rodeo Drive. Sometimes she looks up the addresses of her old workmates from the factory, friends who when they lost their jobs moved away to Kentucky or California, places that because of her IBS, and the demands of her parents, she can never visit for real.
Over the years, Linda has, like many patients with irritable bowel syn- drome, been passed from doctor to doctor. She has been tested for intol- erances and allergies, and has tried cutting out everything from gluten and fat to tomatoes. But she found no relief until she took part in a trial led by Ted Kaptchuk, a professor at Harvard Medical School in Boston. It was a trial that would revolutionize the world of placebo research.
• • •
“You know I’m deviant?” Ted Kaptchuk looks straight at me and I get the sense that he is rather proud of this fact.1 “Yes,” I answer. It’s hard to read anything about the Harvard professor without coming across his unusual past. In fact it seeps from every corner of our surroundings—the house where he lives and works, on a leafy side street in Cambridge, Mas- sachusetts.
I’m asked to remove my shoes as I enter, and offered a cup of Earl Grey tea. Persian rugs cover the wooden floors, and proudly displayed in the hall is a huge brass tea urn. The décor is elegant, featuring period furniture, modern art and shelves filled with books—rows of hardbound doorstops embossed with gold Chinese lettering next to English volumes, from The Jewish Wardrobe to Honey Hunters of Nepal. Through the win- dow I glimpse the nuanced greens and pinks of a manicured ornamental garden that might be more at home in Japan.
Kaptchuk himself has gold rings, big brown eyes and a sweep of gray- ing hair topped by a black skullcap. He likes to quote from historical man- uscripts, and his answers to my questions are accompanied by long pauses and a furrowed brow. I ask him to tell me his own version of the path that brought him here and he says it started when he was a student and he traveled to Asia to study traditional Chinese medicine.
It’s a decision he attributes to “sixties craziness. I wanted to do some- thing anti-imperialist.” He was also interested in Eastern religions and phi- losophies, and the thinking of the Chinese Communist leader Mao Zedong. “Now I think that was a really bad reason to study Chinese medicine. But I didn’t wanted to be co-opted, I didn’t want to be part of the system.”
After four years in Taiwan and China, he returned to the U.S. with a degree in Chinese medicine and opened a small acupuncture clinic in Cambridge. He saw patients with all sorts of conditions, mostly chronic complaints from pain to digestive, urinary and respiratory problems. Over the years, however, he became more and more uncomfortable with his role as a healer. He was good at what he did—perhaps too good. He would see dramatic cures, sometimes before patients had even received their treatment. “I would have patients who left my office totally differ- ent,” he says. “Because they sat and talked to me, and I wrote a prescrip- tion. I was petrified that I was psychic. I thought, Shit, this is crazy.”
Ultimately, Kaptchuk concluded that he didn’t have paranormal pow- ers. But equally, he believed that his patients’ striking recoveries didn’t have anything to do with the needles or the herbs he was prescribing. They were because of something else, and he was interested in finding out what that something was.
In 1998, Harvard Medical School, just down the street from Kaptchuk’s clinic, was looking for an expert in Chinese medicine. The U.S. National Institutes of Health (NIH) was opening a center dedi- cated to funding scientific research into alternative and complementary medicine. Although tiny compared to existing NIH centers investigating cancer, for example, or genetics, it promised to be a useful new source of research dollars for Harvard. “But no one there knew a thing about Chinese medicine or any kind of alternative medicine,” says Kaptchuk. “So they hired me.”
Rather than study Chinese medicine directly, however, he decided to investigate the placebo effect, to find out whether this could explain why his patients did so well. Whereas Benedetti is interested in the molecules and mechanics of the placebo effect, Kaptchuk’s focus is on people. The questions he asks are psychological and philosophical. Why should the expectation of a cure affect us so profoundly? Can the placebo effect be split into different components? Is our response affected by factors such as the type of placebo we take, or the bedside manner of our doctor?
In one of his first trials, Kaptchuk compared the effectiveness of two different kinds of placebo—fake acupuncture and a fake pill—in 270 pa- tients with persistent arm pain.2 It’s a study that makes no sense from a conventional perspective. When comparing two inert treatments— nothing with nothing—you wouldn’t expect to see any difference. Yet Kaptchuk did see a difference. Placebo acupuncture was more effective for reducing the patients’ pain, whereas the placebo pill worked better for helping them to sleep.
This is the problem with placebo effects—in trials they are elusive and ephemeral, rarely disappearing completely but often altering their shape. They change depending on the type of placebo, and they vary in strength between people, conditions and cultures. For example, the percentage of people who responded to placebo in trials of a particular ulcer medication ranged from 59% in Denmark to just 7% in Brazil.3 The same placebo can have positive, zero or negative effects depending on what we’re told about it, and the effects can change over time. Such shifting results have helped to create an aura around the placebo effect as something slightly unscientific if not downright crazy.
But it isn’t crazy. What these results actually show, says Kaptchuk, is that scientists have long gotten their understanding of the placebo effect backwards. When he arrived at Harvard, he says, the experts there told him that the placebo effect “was the effect of an inert substance.” It’s a commonly used description but one that Kaptchuk describes as “com- plete nonsense.” By definition, he points out, an inert substance does not have any effect.
What does have an effect, of course, is our psychological response to those inert substances. Neither fake acupuncture nor a fake pill is in itself capable of doing anything. But patients interpret them in different ways, and that in turn creates different changes in their symptoms.
Most helpful customer reviews
66 of 67 people found the following review helpful.
Current Science on the Importance of the Mind in Fighting Disease and Staying Well
By Spencer in Seattle
As someone with an autoimmune disease (multiple sclerosis), I read quite a bit in the areas of health and medicine, alternative medicine, and the history of medicine. This book, written by a British journalist who also has a PhD in microbiology, gives us a vibrant look at the powers of the mind in healing. She studies the current research and presents it in an accessible way. I'm not at all surprised that this book has rocketed to several top-seller lists.
Note that this book deals a lot with the powers of the placebo effect. The point here is not that doctors should be tricking everyone who is ill, just to make them feel good. Instead, the idea is that the placebo effect shows us certain things that can be harnessed to lead to wellness. For instance, being cared for really helps people heal, as does having belief and simply doing something to try to help with the problem. Our expectations are vitally important when it comes to healing, as are our previous experiences. Many factors determine how we respond to medical treatment and neglect. This book is about understanding those elements and bringing them into regular medical care instead of just relying on fake pills, as we can learn a lot from the placebo effect.
Here are the main things I see as take-aways in this book:
==========================================================
● Because of the importance of the mind/body connection, the placebo effect, and the studies cited by the author, it's extremely important to find a great healthcare provider you really trust. If you don't do this, your chances of doing well are simply undermined because you won't have belief in the person you're working with, and you might not even have belief in yourself. A good provider needs to be empathic and supportive, as their attitude is really beneficial to people going through treatment. The style and quality of your care provider matters a lot.
● For those of us with a serious disease, doing something about it is so much better and more important than doing nothing. This is because doing something -- if it's taking a drug or following a lifestyle "cure" -- harnesses the powers of the mind and body to work for you. Doing what you believe in really matters.
● For some things, the mind/body connection is really helpful: Things like pain, depression, fatigue, nausea, and generally "how we feel" are the most able to be influenced by mind/body interaction.
● Following from this, autoimmune responses are often influenced by the mind/body connection. Said another way, autoimmune diseases are particularly susceptible to mind/body interaction
● For other things, the mind/body connection is much less relevant. Things like infections need antibiotics and things like broken bones need casts.
● Stress is a real killer, as is emphasized in this book over and over. Stress is rooted in our flight-or-fight ancestry, switching on to save our lives. But switching this response on for a long time can result in things like high blood pressure and really damaging your body. With chronic stress, inflammation kicks in, which is not really what you want all the time (especially for those with MS). Stress can even rewire the brain (based on brain-scan research), and this has been documented.
For people with MS in particular and autoimmune diseases in general, there are a few particular take-aways in this book:
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● Biofeedback and meditation can be particularly helpful, but you really need to "put in the hours" giving them time to rewire your brain and whole self. These practices don't heal us over night. You really need to take time to rewire your brain away from a stressed-out neural network.
● When people with MS have flare-ups, not getting too anxious about it is vitally important. This is for two reasons: 1) imagining improvement and thinking positively can actually bring it about, and 2) this point of view can help mitigate stress, thus keeping the exacerbation from getting worse
● With MS, inflammation is the real source of the problem (as our white blood cells are attacking the central nervous system), and stress has been shown to cause swelling. As a result, limiting stress is utterly vital for those of us with MS. Negative worries and anxieties can be equally destructive. Stress kills us in particular, because of the way MS works.
● Treating MS in ways you believe in really matters. Belief and healing go hand in hand. For me, this means that mainstream and alternative approaches can all "work" or be helpful, as long as you are invested in them and coming from a position of belief and positivity.
● Being cared for well is also essential, as the placebo effect is tapped into when you're feeling cared for.
2 of 2 people found the following review helpful.
Serious, Compelling and Mind-Changing Book
By Anne Mills
This book is a great introduction to mind/body phenomena in medicine, because it approaches the topic from a rigorously scientific, evidence-based standpoint. Ms. Marchant is a science and history journalist with a doctorate in microbiology, and without any touch of New Agey credulity. She looks at the ways in which the mind can affect the body's ability to cure itself, looking at individual case histories and at studies of many cases. Much of the evidence she cites is compelling; her arguments are strong enough to make me consider a non-traditional approach to my chronic hip pain, and for someone as science-based as I, that's quite a concession.
Beyond convincing arguments and evidence, Ms. Marchant has written an eminently readable and engrossing book. She makes one thing very clear: the antipathy of the current medical establishment to non-traditional medicine, even when it is shown to be helpful. This is based on the sad fact that it is at present very difficult to make money from an approach that leans to fewer pills, less intervention, and more human contact. Perhaps efforts at cost saving will bring this approach more into the limelight. In the meantime, this book is well worth reading, particularly for those with intractable medical issues.
57 of 61 people found the following review helpful.
Marchant gives us the facts about mind-body interaction... and much more
By Mister Charlie
I thoroughly enjoyed this wide-ranging inquiry into the myriad ways the "workings of the mind" can affect your body.
Jo Marchant,, a PhD in genetics and medical microbiology, and a seasoned author, began her investigation into these phenomena with a great deal of skepticism towards "alternative medicine", and through the course of the book helps the reader understand what pieces of the non-traditional pie are worth further investigation.
If you are skeptical about whack-a-doodle ideas related to your health, Marchant is the ideal author to open your eyes to the possibility that there are clinically-tested ways in which some seemingly whack-a-doodle ideas have proven their mettle. She is ideal because her writing is lively and engaging, and she maintains the open mind and clear eye of the scientist you wish more scientists would emulate.
Throughout the book, though, you can see the challenges presented by the massive medical Establishment and the pharmaceutical industry. Not only are doctors hesitant (or downright hostile) to adopt alternative mind-based practices into their regimen, but there is very little interest in funding research where, at the end of it, no drug can be marketed and profited from. And in this way, the book transforms itself from an "isn't it interesting what the mind can do?" book to more of a wake-up call for the entire medical industry.
Clearly in our society we are dangerously over-medicated. Marchant tells us "the top ten highest grossing drugs in the US help only between 1 in 25 and 1 in 4 of the people who take them." and "psychiatric drugs are responsible for more than half a million deaths in the western world each year." and "Medical errors in hospital are estimated to cause more than 400,000 deaths per year in the US alone". and "According to the US FDA, there are another 2 million serious cases of adverse drug reactions in the US each year, including 100,000 deaths". Even if only 1% of this was true, I wonder why people aren't absolutely outraged and demanding a change in how our medical industry functions.
Here's hoping Marchant's book falls into as many hands as possible, and helps to initiate that change.
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